Neck lumps - RHCG Emergency Department

Warning

Objectives

This guideline is for RHCG Emergency department staff to support assessment, investigation and management of patients presenting with neck lumps.

Scope

Children with neck lumps.

Audience

Clinicians working in the Emergency Department.

Neck lumps are a common presenting complaint to the paediatric emergency department with a wide range of aetiologies. These can be broadly separated into congenital, inflammatory and neoplastic masses. Thorough history taking and detailed examination can aid in diagnosis and management. Inflammatory masses are by far most common, accounting for 75% of neck lumps and 80-90% are benign in origin.

Relevant history

  • Duration
  • Speed of change
  • Associated fever
  • Pain
  • Recent illnesses
  • Risk factor exposure (TB, cats, HIV)
  • Previous episodes

Examination findings

Lump exam

  • Size
  • Consistency
  • Texture
  • Location
  • Single versus multiple
  • Uni- versus bi-lateral
  • Tenderness
  • Skin changes overlying the mass (description of nature of changes essential – including mobility to skin and surrounding tissue)

Systemic exam

  • Hepatomegaly
  • Splenomegaly
  • Other lymphadenopathy (groin/armpit)
  • Rash
  • Well vs unwell child
  • Stridor
  • Dysphagia
  • Drooling
  • Torticollis

Differentials and suggestive history/exam findings

Inflammatory masses (hyperlink to section below – management of inflammatory masses)

  • Reactive lymphadenopathy
    • Concurrent upper respiratory tract infection
    • Any evidence of dental decay or potential intraoral infective focus.
    • Small, “kidney bean size” with smooth surface and mobile to surrounding structures
    • Wax and wane with inter-current illnesses (including skin conditions local to the mass)
  • Lymphadenitis
    • Infectious prodrome (viral or bacterial)
    • Unilateral swelling
    • Usually in anterior triangle
    • Firm, tender mass
    • May have associated fever
  • Abscess
    • Lymphadenitis may develop into abscess
    • Fluctuant mass
  • Deep-seated infections (retropharyngeal abscess)
    • Difficulty swallowing
    • Stridor
    • Altered voice
  • Other (TB, EBV, Cat Scratch, Kawasaki’s, Eczema, Rheumatological disease, other viruses)

Other Inflammatory Causes

Suggestive Features

Mycobacterium Tuberculosis

Exposure (travel/contact), systemic features such as malaise, fever, weight loss. Persistent non tender nodes

EBV

Hepatosplenomegaly, sore throat, fever

Cat Scratch Disease (Bartonella Henselae)

Exposure to cat, persistent tender nodes, fever

Kawasaki Disease

Persistent fever (5 or more days), rash, non-purulent conjunctivitis, strawberry tongue, cracked lips, peeling hands/feet, BCG re-activation

Eczema

Persistent head/neck eczema

Rheumatological conditions (JIA/SLE)

Rash, joint pains, conjunctival changes

Other viruses (CMV, Rubella)

Persistent generalised lymphadenopathy, may be associated hepatosplenomegaly

Congenital masses (hyperlink to section below - management of non-inflammatory masses)

  • Thyroglossal cysts
    • Common
    • Smooth, rounded, midline lump
  • Haemangiomas/Vascular malformations
    • Consider airway haemangiomas
    • Can rapidly increase in size
  • Lymphatic malformation
  • Branchial cleft defects
    • Vary in location depending on which branch affected
  • Sternocleidomastoid Tumour
    • Benign masses resulting in torticollis
    • Fibrous tissue deposition due to in-utero contraction

Neoplastic masses (hyperlink to section below - management of non-inflammatory masses)

  • Lymphoma
  • Leukaemia
  • Thyroid neoplasm
  • Metastases

Although rare, multiple suggestive factors can point towards a neoplastic cause of neck lump. As size and number of masses increases, so does the likelihood of a malignant cause. Having supraclavicular nodes is highly predictive of malignant mass and should prompt investigation. Examination findings of malignant nodes often reveal non-mobile masses tethered to underlying structures. Nodes present for > 6 weeks are more likely to be neoplastic in origin and should also prompt referral. Additionally, systemic features such as persistent fever, lethargy, weight loss, pallor and night sweats should raise the suspicion of neoplastic neck lump.

Management of inflammatory masses

Reactive lymphadenopathy is very common secondary to upper respiratory tract infection. Identifying the focus of infection will guide management. Most commonly, this will be a viral infection and require symptomatic management only. Reassure parents and discuss the natural history of waxing and waning of lymphadenopathy as well as when to seek medical advice as below in addition to red flags:             

  • Persistent lymph node >6weeks AND >2cm
  • Rapidly increasing size – as documented by healthcare provider (GP or previous ED attendance)

When lymphadenitis is diagnosed, treatment with antibiotics should be considered. When the child is clinically well, will tolerate orals and without any red flag features, treatment can be with oral antibiotics. Treatment of choice is 7-days of Co-Amoxiclav and Cefalexin in Penicillin allergic patients.

After successful treatment it is possible that the residual node might remain noticeable for 2-3 months. 

In children with red flag features, features suggestive of an abscess or not tolerating oral intake, referral should be made to ENT to review in the emergency department for consideration of imaging, IV antibiotics and admission. 

Management of non-inflammatory masses

Congenital non-inflammatory masses generally do not require admission to hospital unless there are airway concerns. Sternocleidomastoid tumours should be referred to physiotherapy for treatment.

If a suspected congenital neck mass is identified in ED then patient should be discussed with ED senior decision maker and if ongoing concerns, then the case should be discussed with the on-call ENT team. 

In children where there is a concern of a neoplastic neck lump, additional urgent investigations will be required including bloods, ultrasound and CXR if lymphoma is suspected to assess for evidence of mediastinal widening. Immediate referral to Oncology is appropriate if malignancy is highly suspected or confirmed and these children will be admitted. 

Red flags for immediate ENT referral for acute assessment from ED

Red flags

  • Septic or unwell-looking child
  • Difficulty swallowing
  • Stridor or airway compromise
  • Change in voice
  • Rapidly progressing (significant increase in less than 4 days)
  • Tethered node

When to refer to ENT from ED

  • Red flag features
  • Unable to tolerate oral antibiotics
  • Suspicion of abscess
  • Suspicion of malignancy
  • Suspicion of congenital neck lump
  • Supraclavicular nodes  

When to image and what modality

Ultrasound is the imaging of choice for neck lumps. For those who require inpatient ENT assessment, ultrasound can be carried out the ascertain presence of abscess or suspicion of malignant changes in the lump. All imaging decisions should be made in combination with ENT and radiology teams.

Primary care follow up

Patients discharge from ED on oral antibiotics should be advised of specific red flag features warranting repeat ED attendance. 

They should also be advised to attend their primary care team after the completion of the antibiotic course to ensure no abscess is forming.  If concerns arise that an abscess is forming or the patient develops any red flag features then they should be directed to ED for review.

Further indications for referral to ENT for cervical lymphadenopathy from primary care can be found here - Primary Care referral guidelines: cervical lymphadenopathy - advice for referrers

Editorial Information

Last reviewed: 24/02/2026

Next review date: 28/02/2029

Author(s): Dr Kirsty Kilpatrick, Paediatric Emergency Medicine resident, RHCG, Dr Steve Foster, Paediatric Emergency Medicine Consultant, RHCG (correspondence author).

Author email(s): Steven.Foster@nhs.scot.

Co-Author(s): Stakeholders: Ms Astrid Koenig, ENT Consultant, RHCG;  Dr Ruth Allen, Paediatric Radiology Consultant, RHCG.

Approved By: Paediatric Antimicrobial Management Team & ED Clinical Governance Group