Scottish Paediatric Consensus Treatment Guideline for Paediatric Inflammatory Multisystem Syndrome (1104)

For children with suspected Kawasaki Disease, or children with suspected Macrophage Activation Syndrome (MAS) in the context of known rheumatological disorders see the relevant SPARN guideline: Guidance – Scottish Paediatric and Adolescent Rheumatology Network

For children with suspected Haemophagocytic Lymphohistiocytosis (HLH) please see HLH-Guide-final-version-v1.4-November-2025.pdf 

For children with suspected HLH, MAS without known underlying diagnosis or any other suspected hyperinflammatory disease please arrange urgent multi-disciplinary discussion with paediatric rheumatology and paediatric infectious diseases. Involvement of other specialist teams including critical care, haematology and cardiology should be considered on a case by case basis. An urgent virtual MDT discussion eg via Microsoft teams, arranged and led by a senior clinician from the referring team, should be considered best practice to facilitate efficient early discussion rather than separate referral discussions with each team.